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Aim
Reductions in voltage‐gated sodium channel (Nav1.5) function/expression provide a slowed‐conduction substrate for cardiac arrhythmias. Nedd4‐2, which is activated by calcium, post‐translationally modulates Nav1.5. We aim to investigate whether elevated intracellular calcium ([Ca2+]i) reduces Nav1.5 through Nedd4‐2 and its role in heart failure (HF).
Methods
Using a combination of biochemical,...
AimsBiliary tract obstruction is a common clinical lesion. However, the effect of biliary tract obstruction on intestinal secretion is poorly understood. In this study, we made an investigation on intestinal HCO3− and Cl− secretions in an experimental model of murine biliary duct ligation.
MethodsMurine intestinal mucosal HCO3− and Cl− secretions were examined in vitro in Ussing chambers by pH‐stat...
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