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The histone deacetylase HDAC2, which negatively regulates synaptic gene expression and neuronal plasticity, is upregulated in Alzheimer’s disease (AD) patients and mouse models. Therapeutics targeting HDAC2 hold promise for ameliorating AD-related cognitive impairment; however, attempts to generate HDAC2-specific inhibitors have failed. Here, we take an integrative genomics approach to identify proteins...
Traditional relational database management systems (RDBMS) have shown limitations in storing and analyzing big data. For example, a RDBMS is suitable for transactional operations yet not good at large-scale data analysis and processing, since a large-scale record scan or full table scan is often time-consuming. An efficient storage method for reading and writing big geospatial data is still needed...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.