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Cyclooxygenase-2 (COX-2), a rate limiting step in arachidonic acid cascade, plays a key role in the biosynthesis of prostaglandin E 2 (PGE 2 ) upon inflammatory stimuli, growth factors, hormones and other cellular stresses. Overproduction of PGE 2 stimulates proliferation of various cancer cells, confers resistance to apoptosis and favors metastasis and angiogenesis. The steady-state...
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