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p53-Induced ring-H2 protein (Pirh2), a recently identified ubiquitin–protein ligase, interacts with p27 Kip1 to promote ubiquitination of p27 Kip1 independently of p53. High Pirh2 and low p27 Kip1 immunoreactivity are associated with a poor prognosis in several cancers, including resistant phenotypes. In the present study, we investigated the role of Pirh2 and p27 Kip1...
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