Wyniki wyszukiwania dla: Fernanda Hansen

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artykuł

GABA_A Modulation of S100B Secretion in Acute Hippocampal Slices and Astrocyte Cultures

Adriana Fernanda K. Vizuete, Fernanda Hansen, Carollina Ré, Miriara B. Leal, więcej

Neurochemical Research > 2019 > 44 > 2 > 301-311

Astrocytes are the major glial cells in brain tissue and are involved, among many functions, ionic and metabolic homeostasis maintenance of synapses. These cells express receptors and transporters for neurotransmitters, including GABA. GABA signaling is reportedly able to affect astroglial response to injury, as evaluated by specific astrocyte markers such as glial fibrillary acid protein and the...

artykuł

Glutamatergic Alterations in STZ-Induced Diabetic Rats Are Reversed by Exendin-4

Caroline Zanotto, Fernanda Hansen, Fabiana Galland, Cristiane Batassini, więcej

Molecular Neurobiology > 2019 > 56 > 5 > 3538-3551

Diabetes mellitus is a metabolic disorder that results in glucotoxicity and the formation of advanced glycated end products (AGEs), which mediate several systemic adverse effects, particularly in the brain tissue. Alterations in glutamatergic neurotransmission and cognitive impairment have been reported in DM. Exendin-4 (EX-4), an analogue of glucagon-like peptide-1 (GLP-1), appears to have beneficial...

artykuł

Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis

Adriana Fernanda K. Vizuete, Fernanda Hansen, Elisa Negri, Marina Concli Leite, więcej

Journal of Neuroinflammation > 2018 > 15 > 1 > 1-14

Background Temporal lobe epilepsy (TLE) is the most common form of partial epilepsy and is accompanied, in one third of cases, by resistance to antiepileptic drugs (AED). Most AED target neuronal activity modulated by ionic channels, and the steroid sensitivity of these channels has supported the use of corticosteroids as adjunctives to AED. Assuming the importance of astrocytes in neuronal activity,...

artykuł

Methylglyoxal can mediate behavioral and neurochemical alterations in rat brain

Fernanda Hansen, Pablo Pandolfo, Fabiana Galland, Felipe Vasconcelos Torres, więcej

Physiology & Behavior > 2016 > 164 > PA > 93-101

Diabetes is associated with loss of cognitive function and increased risk for Alzheimer's disease (AD). Advanced glycation end products (AGEs) are elevated in diabetes and AD and have been suggested to act as mediators of the cognitive decline observed in these pathologies. Methylglyoxal (MG) is an extremely reactive carbonyl compound that propagates glycation reactions and is, therefore, able to...

artykuł

Intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation

Núbia Broetto, Fernanda Hansen, Giovana Brolese, Cristiane Batassini, więcej

Brain Research Bulletin > 2016 > 124 > C > 136-143

Intraneuronal aggregates of neurofibrillary tangles (NFTs), together with beta-amyloid plaques and astrogliosis, are histological markers of Alzheimer’s disease (AD). The underlying mechanism of sporadic AD remains poorly understood, but abnormal hyperphosphorylation of tau protein is suggested to have a role in NFTs genesis, which leads to neuronal dysfunction and death. Okadaic acid (OKA), a strong...

artykuł

Peripheral Levels of AGEs and Astrocyte Alterations in the Hippocampus of STZ-Diabetic Rats

Patrícia Nardin, Caroline Zanotto, Fernanda Hansen, Cristiane Batassini, więcej

Neurochemical Research > 2016 > 41 > 8 > 2006-2016

Diabetic patients and streptozotocin (STZ)-induced diabetes mellitus (DM) models exhibit signals of brain dysfunction, evidenced by neuronal damage and memory impairment. Astrocytes surrounding capillaries and synapses modulate many brain activities that are connected to neuronal function, such as nutrient flux and glutamatergic neurotransmission. As such, cognitive changes observed in diabetic patients...

artykuł

Methylglyoxal and carboxyethyllysine reduce glutamate uptake and S100B secretion in the hippocampus independently of RAGE activation

Fernanda Hansen, Cíntia Eickhoff Battú, Márcio Ferreira Dutra, Fabiana Galland, więcej

Amino Acids > 2016 > 48 > 2 > 375-385

Diabetes is a metabolic disease characterized by high fasting-glucose levels. Diabetic complications have been associated with hyperglycemia and high levels of reactive compounds, such as methylglyoxal (MG) and advanced glycation endproducts (AGEs) formation derived from glucose. Diabetic patients have a higher risk of developing neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s...

artykuł

Dietary n‐3 long‐chain polyunsaturated fatty acids modify phosphoenolpyruvate carboxykinase activity and lipid synthesis from glucose in adipose tissue of rats fed a high‐sucrose diet

Lisiane G. Londero, Débora K. Rieger, Fernanda Hansen, Simone L. Silveira, więcej

Cell Biochemistry and Function > 31 > 8 > 636 - 642

Long‐chain polyunsaturated n‐3 fatty acids (n‐3 LCPUFAs) have hypolipidemic effects and modulate intermediary metabolism to prevent or reverse insulin resistance in a way that is not completely elucidated. Here, effects of these fatty acids on the lipid profile, phosphoenolpyruvate carboxykinase (PEPCK) activity, lipid synthesis from glucose in epididymal adipose tissue (Ep‐AT) and liver were investigated...

artykuł

Homocysteine induces energy imbalance in rat skeletal muscle: Is creatine a protector?

Janaína Kolling, Emilene B. S. Scherer, Cassiana Siebert, Fernanda Hansen, więcej

Cell Biochemistry and Function > 31 > 7 > 575 - 584

Homocystinuria is a neurometabolic disease caused by a severe deficiency of cystathionine beta‐synthase activity, resulting in severe hyperhomocysteinemia. Affected patients present several symptoms including a variable degree of motor dysfunction. In this study, we investigated the effect of chronic hyperhomocysteinemia on the cell viability of the mitochondrion, as well as on some parameters of...

artykuł

Increase of extracellular glutamate concentration increases its oxidation and diminishes glucose oxidation in isolated mouse hippocampus: Reversible by TFB‐TBOA

Felipe Vasconcelos Torres, Fernanda Hansen, Lucas Doridio Locks‐Coelho

Journal of Neuroscience Research > 91 > 8 > 1059 - 1065

Glutamate concentration at the synaptic level must be kept low in order to prevent excitotoxicity. Astrocytes play a key role in brain energetics, and also astrocytic glutamate transporters are responsible for the vast majority of glutamate uptake in CNS. Experiments with primary astrocytic cultures suggest that increased influx of glutamate cotransported with sodium at astrocytes favors its flux...

artykuł

Interleukin-6-induced S100B secretion is inhibited by haloperidol and risperidone

Daniela Fraga de Souza, Krista Wartchow, Fernanda Hansen, Paula Lunardi, więcej

Progress in Neuropsychopharmacology & Biological Psychiatry > 2013 > 43 > Complete > 14-22

Although inflammation may be a physiological defense process, imbalanced neuroinflammation has been associated with the pathophysiology of brain disorders, including major depression and schizophrenia. Activated glia releases a variety of pro-inflammatory cytokines that contribute to neuronal dysfunction. Elevated levels of S100B, a glia derived protein, have been observed in the serum and CSF of...

artykuł

Non-specific inhibitors of aquaporin-4 stimulate S100B secretion in acute hippocampal slices of rats

Caroline Zanotto, Renata Torres Abib, Cristiane Batassini, Lucas Silva Tortorelli, więcej

Brain Research > 2013 > 1491 > Complete > 14-22

Aquaporin-4 (AQP-4) is the principal brain water channel and is predominantly expressed in astrocytes suggesting its dynamic involvement in water homeostasis in brain tissue. Due to the co-localization of AQP-4 and inward rectifier K ⁺ channels Kir 4.1, a functional coupling between these proteins has been proposed. AQP-4 has a putative role in the physiopathology of brain disorders including...

artykuł

Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells

Fernanda Hansen, Daniela Fraga Souza, Simone da Luz Silveira, Ana Lúcia Hoefel, więcej

Metabolic Brain Disease > 2012 > 27 > 4 > 531-539

Methylglyoxal is a dicarbonyl compound that is physiologically produced by enzymatic and non-enzymatic reactions. It can lead to cytotoxicity, which is mainly related to Advanced Glycation End Products (AGEs) formation. Methylglyoxal and AGEs are involved in the pathogenesis of Neurodegenerative Diseases (ND) and, in these situations, can cause the impairment of energetic metabolism. Astroglial cells...

artykuł

Effects of chronic administration of tryptophan with or without concomitant fluoxetine in depression-related and anxiety-like behaviors on adult rat

Fernanda Hansen, Diogo Losch de Oliveira, Francieli Ubirajara Índia Amaral, Fabiana Salvatori Guedes, więcej

Neuroscience Letters > 2011 > 499 > 2 > 59-63

Depression and anxiety play an important role in decreasing quality of life worldwide. Since tryptophan is a serotonin precursor and low levels of serotonin seems to be related to depression, the effect of oral tryptophan has been investigated for possible potentiation of the action of antidepressant drugs. We investigated the effects of chronically administered tryptophan (50mg/kg/day, p.o.) with...

artykuł

Effects of glyoxal or methylglyoxal on the metabolism of amino acids, lactate, glucose and acetate in the cerebral cortex of young and adult rats

Betina Schmidt, Adriano Martimbianco de Assis, Cíntia Eickhoff Battu, Débora Kurle Rieger, więcej

Brain Research > 2010 > 1315 > Complete > 19-24

The in vitro effects of glyoxal and methylglyoxal on the metabolism of glycine, alanine, leucine, glutamate, glutamine, glucose, lactate and acetate were evaluated in cortico-cerebral slices from young (10-day-old) or adult (3-month-old) rats. In a first set of experiments with cortico-cerebral slices from young animals, the compounds glyoxal or methylglyoxal at 400 μM, increased the oxidation of...

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