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Efficacy of salicylic acid as a treatment for diabetes was first established well over a century ago. Antihyperglycaemic effects are thought to include improved peripheral insulin sensitivity and suppression of hepatic glucose production. For most of this period, the molecular mechanisms underlying these effects have been poorly understood and these are still a focus of considerable research, which...
Nuclear factor-κB (NF-κB) is an important transcription factor involved in various biological processes, including carcinogenesis. However, it is unknown whether NF-κB activation is involved in gastric carcinogenesis.To explore the roles of inhibitor of κB kinase (IKKβ), the key kinase for NF-κB activation, in gastric epithelium, we established a conditional gastric mucosal epithelium knockout mouse...
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