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Glycogen synthase kinase-3 (GSK-3) is a kind of serine-threonine protein kinase. It places important roles in several signaling pathways and it is a key therapeutic target for a number of diseases, such as diabetes, cancer, Alzheimer’s disease and chronic inflammation. Mg2+ ions which interact with ATP are conserved in GSK. They are important in phosphoryl transfer. Li+ is an inhibitor for GSK-3....
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