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An in vitro method for measuring aromatase cytochrome P450 enzyme (P450 AROM ) in human granulosa cells (GC) has been developed, based on binding of the 11 C-labeled aromatase inhibitor vorozole. GC were obtained following superstimulation during in vitro fertilisation. The method revealed a binding affinity (K d ) of 0.4 nM and a maximum binding (B ...
[N-methyl- 11 C]Vorozole, a high-affinity aromatase-binding radiotracer, was synthesized through N-methylation of the corresponding nor-vorozole derivative using [ 11 C]methyl iodide. [N-methyl- 11 C]Vorozole was obtained in 53-56% radiochemical yield based on [ 11 C]methyl iodide within 40 min of the end of radionuclide production. The final formulation...
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