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The notion that certain proteins lack intrinsic globular structure under physiological conditions and that the attainment of fully folded structure only occurs upon the binding of target molecules has been recently gaining popularity. We report here the solution structure of the PTB domain of the signaling protein Shc in the free form. Comparison of this structure with that of the complex form, obtained...
The crystal structure of the Disabled-1 PTB domain in a ternary complex with the phosphoinositide PI-4,5P 2 and an NPVY peptide of the apolipoprotein E receptor-2 reveals how this conserved scaffold simultaneously recognizes two distinct biological ligands required for signaling through this family of receptors.
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