Wyniki wyszukiwania dla: Jian Wan

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Incidence and disease‐related risk factors for cerebrovascular accidents in patients with inflammatory bowel diseases: A systematic review and meta‐analysis

Jian Wan, Xuan Wang, Yu Jie Zhang, Yue Yin, więcej

Journal of Digestive Diseases > 24 > 10 > 504 - 515

Objectives Risk of cerebrovascular accidents (CVAs) in patients with inflammatory bowel disease (IBD) remains inconclusive. In this systematic review and meta‐analysis, we aimed to estimate the incidence of and identify the risk factors for CVA in patients with IBD. Methods PubMed, EMBASE and Web of Science were searched for articles published up to January 13, 2023 to identify those reported the...

artykuł

Development and validation of a nomogram to provide individualized predictions of functional outcomes in patients with convulsive status epilepticus at 3 months: The modified END‐IT tool

Xuan Wang, Yuan‐Yuan Wang, Qiong Gao, Yao‐Yao Zhang, więcej

CNS Neuroscience & Therapeutics > 29 > 12 > 3935 - 3942

Aims The prediction of outcomes in convulsive status epilepticus (CSE) remains a constant challenge. The Encephalitis‐Nonconvulsive Status Epilepticus‐Diazepam Resistance‐Image Abnormalities‐Tracheal Intubation (END‐IT) score was a useful tool for predicting the functional outcomes of CSE patients, excluding cerebral hypoxia patients. With further understanding of CSE, and in view of the deficiencies...

artykuł

Chiral Ru^II‐Pt^II Complexes Inducing Telomere Dysfunction against Cisplatin‐Resistant Cancer Cells

Kai Xiong, Cheng Ouyang, Jiaqi Liu, Johannes Karges, więcej

Angewandte Chemie > 134 > 33 > n/a - n/a

The application of G‐quadruplex stabilizers presents a promising anticancer strategy. However, the molecular crowding conditions within cells diminish the potency of current G‐quadruplex stabilizers. Herein, chiral Ru^II‐Pt^II dinuclear complexes were developed as highly potent G‐quadruplex stabilizers even under challenging molecular crowding conditions. The compounds were encapsulated with biotin‐functionalized...

artykuł

Chiral Ru^II‐Pt^II Complexes Inducing Telomere Dysfunction against Cisplatin‐Resistant Cancer Cells

Kai Xiong, Cheng Ouyang, Jiaqi Liu, Johannes Karges, więcej

Angewandte Chemie International Edition > 61 > 33 > n/a - n/a

artykuł

Prevalence of inflammatory bowel disease in patients with primary sclerosing cholangitis: A systematic review and meta‐analysis

Yujie Zhang, Xinbao Gao, Zhiyi He, Hui Jia, więcej

Liver International > 42 > 8 > 1814 - 1822

Background and Aim Previous studies have established an association between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis (UC). The disease burden of IBD in PSC patients was not well estimated. The study aimed to quantify the pooled prevalence of IBD in PSC and to investigate whether subtypes of PSC and sex influence the...

artykuł

Disease burden of primary gallbladder and biliary tract cancers associated with body mass index in 195 countries and territories, 1990‐2017: A systematic analysis for the Global Burden of Disease Study 2017

Shan Wu, Ran Zhao, Qian Zhuang, Meng Ting Li, więcej

Journal of Digestive Diseases > 23 > 3 > 157 - 165

Objective To investigate the incidence of primary gallbladder and biliary tract cancer, mortality and disability‐adjusted life years (DALY) of the global burden from 1990 to 2017. Methods Data of 195 countries and territories from 1990 to 2017 were extracted from the Global Health Data Exchange. The age‐standardized incidence rate (ASIR) and estimated annual percentage change (EAPC) were employed...

artykuł

Systematic review with meta‐analysis: incidence and factors for progression to advanced neoplasia in inflammatory bowel disease patients with indefinite and low‐grade dysplasia

Jian Wan, Xuan Wang, Yujie Zhang, Min Chen, więcej

Alimentary Pharmacology & Therapeutics > 55 > 6 > 632 - 644

Background Due to limited research on the natural history of indefinite for dysplasia (IND) and low‐grade dysplasia (LGD) in inflammatory bowel disease (IBD), the management of these patients is controversial. Aims This systematic review and meta‐analysis aimed to estimate the incidence and identify the risk factors for advanced neoplasia in IBD patients with IND and LGD. Methods PubMed, Embase...

artykuł

Engineering Ultrasmall Ferroptosis‐Targeting and Reactive Oxygen/Nitrogen Species‐Scavenging Nanozyme for Alleviating Acute Kidney Injury

Keyi Wang, Yang Zhang, Weipu Mao, Wei Feng, więcej

Advanced Functional Materials > 32 > 10 > n/a - n/a

Acute kidney injury (AKI) is a serious renal dysfunction syndromes, which predominantly correlates with the excess production of endogenous reactive oxygen/nitrogen species (RO/NSs), triggering a series of pathological processes including cellular apoptosis, renal fibrosis, and ferroptosis. Ferroptosis as an iron‐dependent nonapoptotic regulated cell death is extensively involved in renal damage....

artykuł

The feasibility of cap‐assisted routine adult colonoscope for therapeutic endoscopic retrograde cholangiopancreatography in patients with Roux‐en‐Y reconstruction after total gastrectomy

Jian Bo Ni, Mei Ying Zhu, Kai Li, Wei Ming Dai, więcej

Journal of Digestive Diseases > 22 > 12 > 721 - 726

Objectives Endoscopic retrograde cholangiopancreatography (ERCP) in patients with Roux‐en‐Y reconstruction after total gastrectomy is difficult to be performed using routine tools. The aim of this study was to evaluate the feasibility and safety of cap‐assisted routine adult colonoscope (CARAC) for ERCP in these patients. Methods Sixteen consecutive patients with indications of ERCP who had previously...

artykuł

Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II

Kai Xiong, Chen Qian, Yixian Yuan, Lin Wei, więcej

Angewandte Chemie International Edition > 59 > 38 > 16631 - 16637

Inducing necroptosis in cancer cells is an effective approach to circumvent drug‐resistance. Metal‐based triggers have, however, rarely been reported. Ruthenium(II) complexes containing 1,1‐(pyrazin‐2‐yl)pyreno[4,5‐e][1,2,4]triazine were developed with a series of different ancillary ligands (Ru1‐7). The combination of the main ligand with bipyridyl and phenylpyridyl ligands endows Ru7 with superior...

artykuł

Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II

Kai Xiong, Chen Qian, Yixian Yuan, Lin Wei, więcej

Angewandte Chemie > 132 > 38 > 16774 - 16780

artykuł

The efficacy and safety of balloon dilation for unresectable malignant biliary obstruction before placement of self‐expanding metal stents

Zhen Yang Shen, Jun Jun Wang, Lun Gen Lu, Rong Wan, więcej

Journal of Digestive Diseases > 21 > 5 > 293 - 300

Objective To evaluate whether patients with malignant biliary obstruction (MBO) benefit from balloon dilation before the placement of a self‐expanding metal stent (SEMS) for palliative biliary drainage. Methods Consecutive patients who underwent endoscopic retrograde cholangiopancreatography with SEMS placement for palliative management of MBO were retrospectively included. Comparative analyses...

artykuł

Using GRGDSPC peptides to improve re‐endothelialization of decellularized pancreatic scaffolds

Jian Wan, Lei Wang, Yan Huang, Haowen Fan, więcej

Artificial Organs > 44 > 4 > E172 - E180

Engineering of functional vascularized pancreatic tissues offers an alternative way to solve the perpetual shortage of organs for transplantation. However, revascularization remains a major bottleneck in biological engineering, which limited the further clinical applications of this strategy. In this study, an efficient approach for enhancing re‐endothelialization of rat decellularized pancreatic...

artykuł

Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects

Yunyuan Huang, Lin Wei, Xinya Han, Haifeng Chen, więcej

European Journal of Medicinal Chemistry > 2019 > 184 > C

Fructose-1,6-bisphosphatase (FBPase) is an essential enzyme of GNG pathway. Significant advances demonstrate the FBPase plays a critical role in treatment of diabetes. Numerous FBPase inhibitors were developed by targeting AMP site, nevertheless, none of these inhibitors has exhibited suitable potency and druggability. Herein, a new allosteric site (C128) on FBPase was discovered, and several nitrostyrene...

artykuł

Platooning Control for Sailboats Using a Tack Strategy

Christophe Viel, Ulysse Vautier, Jian Wan, Luc Jaulin

International Journal of Control, Automation and Systems > 2019 > 17 > 9 > 2310-2320

This paper addresses the problem of platooning control for a fleet of sailboats. A quadrilateral path is proposed to avoid going into the wind. A tack strategy is defined to go front the wind, stay in a short corridor and regulate the sailboat acceleration, which is a challenging task in comparison to autonomous underwater vehicles (AUVs) or surface vehicles that can use motors for such regulation...

artykuł

Systematic review with meta‐analysis: Chromoendoscopy versus white light endoscopy in detection of dysplasia in patients with inflammatory bowel disease

Jian Wan, Xuan Wang, Zhi Ping Yang, Kai Chun Wu

Journal of Digestive Diseases > 20 > 4 > 206 - 214

Objective To compare chromoendoscopy (CE) and white light endoscopy (WLE) for dysplasia surveillance in patients with inflammatory bowel disease (IBD). Methods We conducted a meta‐analysis of 6 randomized controlled trials (RCTs) and 5 prospective studies and compared the CE and WLE groups. A fixed‐effect model was used unless the heterogeneity was high. Results CE detected more patients with...

artykuł

Design, synthesis and algicides activities of thiourea derivatives as the novel scaffold aldolase inhibitors

Shan Xiao, Lin Wei, Zongqin Hong, Li Rao, więcej

Bioorganic & Medicinal Chemistry > 2019 > 27 > 5 > 805-812

By using a new Fragment-Based Virtual Screen strategy, two series of novel FBA-II inhibitors (thiourea derivatives) were de novo discovered based on the active site of fructose-1, 6-bisphosphate aldolase from Cyanobacterial (CyFBA). In comparison, most of the N-(2-benzoylhydrazine-1-carbonothioyl) benzamide derivatives (L14∼L22) exhibit higher CyFBA-II inhibitory activities compared to N-(phenylcarbamothioyl)...

artykuł

microRNA-690 regulates induced pluripotent stem cells (iPSCs) differentiation into insulin-producing cells by targeting Sox9

Yang Xu, Yan Huang, Yibing Guo, Yicheng Xiong, więcej

Stem Cell Research & Therapy > 2019 > 10 > 1 > 1-13

Background The regulatory mechanism of insulin-producing cells (IPCs) differentiation from induced pluripotent stem cells (iPSCs) in vitro is very important in the phylogenetics of pancreatic islets, the molecular pathogenesis of diabetes, and the acquisition of high-quality pancreatic β-cells derived from stem cells for cell therapy. Methods miPSCs were induced for IPCs differentiation. miRNA microarray...

artykuł

FcRγ deficiency improves survival in experimental sepsis by down-regulating TLR4 signaling pathway

Zhi-Min Wei, Zhuo Wang, Xiao-Jian Wan, Xian-Jing Li, więcej

Immunologic Research > 2019 > 67 > 1 > 77-83

Fc receptor common γ signaling chain (FcRγ), a common subunit shared by Fc receptors (FcγRI, III, IV, FcαRI, and FcεRI), is an important immune regulator both in innate and adaptive immunity. Previous studies have shown that FcRγ was a potential target of inflammatory diseases, whereas the role of FcRγ in sepsis has been poorly understood. In this study, we found that deficiency of FcRγ resulted in...

artykuł

Falcon: An ambient temperature aware thermal control policy for IoT gateways

Youhuizi Li, Mohit Kumar, Weisong Shi, Jian Wan

Sustainable Computing: Informatics and Systems > 2017 > 16 > C > 48-55

With the blooming of the Internet of Things (IoT), the demand for smart gateways that can offload the computation and communication tasks of IoT equipment is fast growing. Gateways are the bridge between the connected devices and the Internet, and their reliability is very important. According to literature, the reliability of electronic hardware components is closely related to their operating temperature...

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