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Δ 9 -Tetrahydrocannabinol from Cannabis sativa is mimicked by cannabimimetic analogs such as CP55940 and WIN55212-2, and antagonized by rimonabant and SR144528, through G-protein-coupled receptors, CB 1 in the brain, and CB 2 in the immune system. Eicosanoids anandamide and 2-arachidonoylglycerol are the ''endocannabinoid'' agonists for these receptors. CB 1 receptors...
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