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Background Intracellular accumulation of tau as neurofibrillary tangles (NFTs) is the hallmark of Alzheimer’s disease (AD) as well as in other tauopathies. Tau is present not only in the cytoplasm but also in the extracellular space such as cerebrospinal fluid (CSF) and brain interstitial fluid (ISF). Although clearance is one critical parameter leading to such intracellular/extracellular tau accumulation,...
Purpose To identify the molecules responsible for amyloid β-peptide (1–40) (Aβ(1–40)) uptake by the liver, which play a major role in the systemic clearance of Aβ(1–40). Methods The liver uptake index method was used to examine the mechanisms of Aβ(1–40) uptake by the liver in vivo. Results [125I]Aβ(1–40) uptake by the rat liver was concentration-dependent (50% saturation concentration = 302 nM)....
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