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To investigate the events leading to the depletion of CD4 + T lymphocytes during long-term infection of human immunodeficiency virus type 1 (HIV-1), we infected human CD34 + cells-transplanted NOD/SCID/IL-2Rγ null mice with CXCR4-tropic and CCR5-tropic HIV-1. CXCR4-tropic HIV-1-infected mice were quickly depleted of CD4 + thymocytes and both CD45RA + naïve and...
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