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To date, we still lack an ideal strategy for designing envelope glycoprotein (Env) vaccines to elicit potent protective antibodies against HIV-1 infection. Since the human hepatitis B virus surface antigen (HBsAg) is representative of effective vaccines that can induce ideal humoral immune responses, knowledge of how it elicits antibody responses and T helper cells would be an useful reference for...
To develop a safer, more immunogenic and efficacious vaccine against Streptococcus equi ssp. zooepidemicus (SEZ) infections, the gene of M-like protein (SzP) was placed under the strong vaccinia virus promoter P28 and then inserted into swinepox virus (SPV) genome. The recombinant swinepox virus (rSPV-szp) was isolated in a non-selective medium by the co-expression of Escherichia coli LacZ gene and...
The tumor specific antigen epitope melanoma antigen A1 161–169 (MAGE-A1 161–169 ) was displayed on the major protein (pVIII) of the filamentous bacteriophage (fd). The immune responses of the phage display particles expressing MAGE-A1 161–169 in mice were studied. Using phage display particles as vaccine was effective in affording protection from tumor growth, inducing growth...
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