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Both cardiovascular magnetic resonance (CMR) and 3D transthoracic echocardiography (3DE) can quantify right ventricular (RV) end diastolic volume (EDV) and ejection fraction (EF) accurately. This study was designed to estimate sample sizes and imaging costs to detect changes in RV EDV and EF using 3DE and CMR for future pulmonary arterial hypertension (PAH) drug trials.Same day CMR and 3DE were performed...
The goal of this study was to develop a near-automated technique for the segmentation of left ventricular (LV) endo- and epicardial as well as right ventricular (RV) endocardial contours from cardiac magnetic resonance (CMR) images. The newly developed technique was tested against conventional manual tracing. Our approach is based on a 3D narrow-band statistical level-set algorithm (applied to a stack...
We developed an automated technique for non-rigid image registration as a basis for tracking the heart in contrast-enhanced cardiac magnetic resonance (CMR) image sequences. The goal of the present work was to validate this technique against conventional manual analysis. Our approach is based on a multi-scale extension of the normalized 2D cross-correlation algorithm in combination with level-set...
The ability of multidetector computed tomography (MDCT) to detect stress-induced myocardial perfusion abnormalities is of great clinical interest as a potential tool for the combined evaluation of coronary stenosis and its significance. However, stress testing requires repeated scanning, which is associated with additional radiation exposure and iodine contrast. Our goal was to determine the effects...
We have recently developed an automated technique using noise-based level-set methods and non-rigid registration for endocardial and epicardial border detection as a basis for perfusion quantification from cardiac magnetic resonance (CMR) images. The goal of the present work was to validate this technique against conventional manual analysis both directly and using quantitative coronary angiography...
Pre-surgical planning of mitral valve (MV) repair in patients with Barlow's disease (BD) and fibroelastic deficiency (FED) is challenging due to inability to accurately assess the complexity of MV prolapse. We hypothesized that the etiology of degenerative MV disease (DMVD) could be objectively and accurately determined using morphologic analysis of MV geometry from real-time 3D echocardiographic...
We developed a method for automated quantification of myocardial perfusion from cardiac magnetic resonance (CMR) images. Our approach uses region-based and edge-based level set techniques for endocardial and epicardial border detection combined with non-rigid registration achieved by a 2D multi-scale cross-correlation and contour adaptation. This method was tested on 66 short-axis image sequences...
Although abnormal motion of the interventricular septum (IVS) caused by elevated right ventricular pressure in patients with pulmonary hypertension (PH) is easy to recognize visually, determination of the severity of PH relies on measurements of pulmonary arterial pressure (PAP). We hypothesized that quantitative 3D analysis of regional IVS curvature throughout the cardiac cycle could be used to differentiate...
Left ventricular (LV) remodeling is usually assessed using changes in LV volume, while disregarding regional changes that may occur independently of volume. We hypothesized that 3D analysis of regional endocardial curvature could provide useful information on localized remodeling. Cardiac magnetic resonance (CMR) images were acquired in 44 patients: 14 normal controls (NL), 15 with dilated cardiomyopathy...
Combined assessment of left ventricular (LV) shape and function could provide new insights into the process of LV remodeling. Real-time 3D echocardiography (RT3DE) allows rapid and accurate semi-automated extraction of LV endocardial surfaces. Our aims were to quantify LV morphology both globally and regionally, using new ellipsoidal (E), spherical (S) and conical (C) shape indices, in a large population...
Real-time 3D echocardiography (RT3DE), cardiac magnetic resonance (CMR) and cardiac computed tomography (CCT) can quantify right ventricular (RV) volume and overcome the limitations 2D echocardiography that stem from the unique geometry of the right ventricle. We tested a new technique for volumetric analysis of the right ventricle designed for RT3DE, CMR and CCT (TomTec) on images obtained in RV-shaped...
Aortic stenosis (AS) is the most common native valve disease. The assessment of its severity is routinely performed using transthoracic 2D echocardiography. In particular, aortic valve area (AVA) is usually assessed by continuity equation, although this measurement relies on geometrical assumptions, or by planimetry on transesophageal echocardiography. Accordingly, the aim of this study was to develop...
Mitral effective regurgitant orifice area (EROA) using the flow convergence (FC) method is the current method of choice for quantifying the severity of mitral regurgitation (MR). However, this methodology has limitations, especially in patients with complex mitral valve (MV) pathology. The superior image quality of the transesophageal real-time 3D echocardiography (RT3D-TEE) offers an opportunity...
Multi-detector computed tomography (MDCT) assessment of myocardial perfusion is based on visualization of 2D slices. To overcome the subjective nature of this analysis, we developed a new technique for quantification of myocardial perfusion from MDCT 3D datasets and tested it against nuclear myocardial perfusion imaging (MPI). MDCT datasets of 44 patients were analyzed to generate bull's eye display...
Although 2D speckle tracking echocardiography (STE) has been shown useful for the assessment of regional left ventricular (LV) function, it is limited by its 2D nature. Our goal was to evaluate new 3D-STE software by comparing regional wall motion (RWM) measurements against 2D-STE, and testing its ability to identify RWM abnormalities. 2D and real-time 3D datasets obtained in 32 subjects were analyzed...
Mitral valve (MV) repair is the preferential treatment for mitral regurgitation (MR) associated with degenerative MV disease, and the functional benefits of early surgery are known. Our goal was to evaluate the changes in LV shape following MV repair, using a new method based on real-time 3D echocardiography (RT3DE). Fifty patients with severe asymptomatic MR were enrolled. Transthoracic RT3DE imaging...
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