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Interleukin (IL)-17F is involved in lung inflammation, but the effect of IL-17F on endothelial permeability and its signaling pathway remain ill-defined. The current study sought to investigate the effect of IL-17F on endothelium and assess the role of protein kinase C (PKC) and src-suppressed C kinase substrate (SSeCKS) in this process.Rat pulmonary microvascular endothelial monolayers were constructed...
Objective The aim of the study was to investigate the role of src-suppressed C kinase substrate (SSeCKS) in the modulation of rat pulmonary microvascular endothelial cells (RPMVEC) permeability elicited by interleukin (IL)-1β and tumor necrosis factor (TNF)-α. Methods The gene expression of SSeCKS was analyzed by reverse transcription-polymerase chain reaction. Immunoblotting was used to determine...
Electrochemotherapy (ECT) is a new efficient approach which treats tumor by electroporation and chemotherapeutic agents. Electroporation can deliver exogenous molecules such as drugs into cell by pulsed electric fields through a temporary increase in cell membrane permeability. It results in much higher uptake of the drugs and better effect of antitumoral treatment. We have performed the experiments...
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