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A series of steroidal compounds were synthesized in order to evaluate the possible influence of the configuration of a stereocenter in the 17β-side chain on the inhibitory activity on the enzyme 5α-reductase (5AR). For this purpose diastereomerically pure 4-azasteroids epimers at C-22 were prepared (compounds 1-11) and tested as inhibitors of 5AR in 'in vitro' tests. The obtained data showed that...
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