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Third harmonic generation (THG) microscopy was used as a noninvasive technique for in vivo investigations of the osteocytic lacunar-canalicular network (LCN) in the mouse calvarium. The origin of THG contrast was investigated by simultaneous imaging with multiphoton excitation fluorescence. The THG signal in lacuna originates from the bone-interstitial fluid boundary and the interstitial fluid-osteocyte...
Detection and quantification of rare circulating cells in biological tissues is an important problem and has many applications in biomedical research. Current methods normally involve extraction of blood samples and counting of cells ex vivo, or the use of microscopy-based fluorescence in vivo flow cytometry. The goal of this work is to develop an instrument for non-invasively enumerating very rare...
I will focus on tracking cancer cells, immune cells, and stem cells in vivo using (i) intravital microscopy for 3D tissue imaging, and (ii) in vivo flow cytometry for detection and quantification of circulating cells.
Current research on multiphoton autofluorescence microscopy is primarily focused on imaging the signal from reduced nicotinamide adenine dinucleatide (NADH) in tissue. NADH levels in cells are useful reporters of metabolic information, as well as early indicators in precancer and cancer diagnosis. While NADH is typically imaged in the 400-500 nm spectral window, the amino acid tryptophan is the major...
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