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Ein elektrochemischer Biosensor (E‐CRISPR), der auf CRISPR‐Cas12a (cpf1) basiert, wird von Y. Dai, A. I. Caplan, C. C. Liu et al. in ihrem Forschungsartikel auf S. 17560 vorgestellt. Erkennung und nachfolgende Spaltungsaktivitäten von CRISPR‐Cas12a machen CRISPR zu einem integrierten Sensor‐ und Aktuatorsystem. Transduktion der CRISPR‐Aktivität durch Elektrochemie liefert einen elektrochemischen Biosensor...
An accurate, rapid, and cost‐effective biosensor for the quantification of disease biomarkers is vital for the development of early‐diagnostic point‐of‐care systems. The recent discovery of the trans‐cleavage property of CRISPR type V effectors makes CRISPR a potential high‐accuracy bio‐recognition tool. Herein, a CRISPR‐Cas12a (cpf1) based electrochemical biosensor (E‐CRISPR) is reported, which is...
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