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The addition of oligosaccharides to proteins is a significant posttranslational modification that modulates protein structure, function and localization. Glycans are vital for development in all eukaryotes and are profoundly connected to a large number of human diseases, ranging from glycan genetic diseases to autoimmune disorders and cancer. Glycans present a difficult challenge in the analytical...
The fundamental importance of correct protein glycosylation is abundantly clear in a group of diseases known as congenital disorders of glycosylation (CDG). In these diseases, where sugars may be entirely absent or incorrectly processed, many proteins are affected [c1] such that their biological functions are compromised. This disorder gives rise to a wide range of severe clinical conditions, including...
This chapter contains sections titled:
Introduction
Oligosaccharide Structure and Heterogeneity
Assembly and Processing of N‐Linked Oligosaccharides on IgG
Glycan Analysis of IgG by High Performance Liquid Chromatography (HPLC)
Preparation of Homogeneous Fc Glycoforms
Influence of Fc Glycosylation on Biological Activities of IgG
IgG Glycosylation in Diseases
Conclusion
Acknowledgments
References
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