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Background
Pre‐transplant modification of porcine islets may improve their suitability for clinical use in diabetes management by supporting graft function and reducing the potential for xeno‐rejection. The present study investigates intra‐graft incorporation of stem cells that secrete beta (β)‐cell trophic and immunomodulatory factors to preserve function and alter immune cell responsiveness to...
Modification of human islets prior to transplantation may improve long‐term clinical outcome in terms of diabetes management, by supporting graft function and reducing the potential for allo‐rejection. Intragraft incorporation of stem cells secreting beta (β)‐cell trophic and immunomodulatory factors represents a credible approach, but requires suitable culture methods to facilitate islet alteration...
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