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We investigated the effect of interaction between lung fibroblasts and macrophages on macrophage inflammatory protein 1α (MIP-1α) production by macrophages. In a co-culture system consisting of WI-38 lung fibroblasts layered over THP-1 macrophages stimulated with lipopolysaccharide (LPS), MIP-1α production by THP-1 was significantly lower in co-culture with WI-38 than in THP-1 alone. Treatment with...
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