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From the biochemistry of testicular and adrenal steroids to the mysteries of brain steroid biosynthesis and from pharmacy and pharmacology to neuropharmacology and neurosciences were two transitions in my scientific career where Erminio (Mimo) Costa played a catalytic role. A review of the years and findings that contributed in our understanding of the link between benzodiazepines and neurosteroid...
High doses of diazepam (10.0–20.0 mg/kg) were shown to reduce the volume of acute inflammatory paw edema in rats as a response to carrageenan administration. This effect was attributed to an action of diazepam on the peripheral-type benzodiazepine receptor (PBR) present in the adrenal and/or immune/inflammatory cells. The present study was undertaken to analyze the involvement of nitric oxide (NO)...
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