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The attenuated equine infectious anemia virus (EIAV) vaccine was the first attenuated lentivirus vaccine to be used in a large-scale application and has been used to successfully control the spread of equine infectious anemia (EIA) in China. To better understand the potential role of cytokines in the pathogenesis of EIAV infection and resulting immune response, we used branched DNA technology to compare...
Preliminary studies revealed that the gene of the gp45 transmembrane protein (TM) of the attenuated equine infectious anemia virus (EIAV) vaccine strain EIAV FDDV13 had a high frequency of a premature stop codon at position 261W, which generated a 154-residue truncation at the C-terminus. EIAV FDDV-TM36 , a recombinant virus with the TM truncated at the intracytoplasmic (CT) domain...
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