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Lipid Nanoparticles
In article number 2309200, Haitao Yu, Calum J. Drummond, Jiali Zhai, and co‐workers revealed the intriguing pH‐sensitive, non‐ordered to ordered lyotropic liquid crystalline mesophase transformation of lipid nanoparticles containing the COVID‐19 mRNA vaccine ionizable lipids. Using high‐throughput synchrotron small angle X‐ray scattering, membrane fusogenic cubic and hexagonal...
Self‐assembled lipid nanoparticles (LNPs), serving as essential nanocarriers in recent COVID‐19 mRNA vaccines, provide a stable and versatile platform for delivering a wide range of biological materials. Notably, LNPs with unique inverse mesostructures, such as cubosomes and hexosomes, are recognized as fusogenic nanocarriers in the drug delivery field. This study delves into the physicochemical properties,...
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