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This work proposes the concept of single‐cell microRNA (miR) therapy and proof‐of‐concept by engineering a nanopipette for high‐precision miR‐21‐targeted therapy in a single HeLa cell with sensitive photoelectrochemical (PEC) feedback. Targeting the representative oncogenic miR‐21, the as‐functionalized nanopipette permits direct intracellular drug administration with precisely controllable dosages,...
The practical application of Li‐S batteries is still severely restricted by poor cyclic performance caused by the intrinsic polysulfides shuttle effect, which is even more severe under the high‐temperature condition owing to the inevitable increase of polysulfides’ solubility and diffusion rate. Herein, tungsten‐doped vanadium dioxide (W‐VO2) micro‐flowers are employed with first‐order metal‐insulator...
Caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), coronavirus disease 2019 (COVID‐19) has shown extensive lung manifestations in vulnerable individuals, putting lung imaging and monitoring at the forefront of early detection and treatment. Magnetic particle imaging (MPI) is an imaging modality, which can bring excellent contrast, sensitivity, and signal‐to‐noise ratios to lung...
The use of bacteria and their biotic components as therapeutics has shown great potential in the treatment of diseases. Orally delivered bacteria improve patient compliance compared with injection‐administered bacteria and are considered the preferred mode. However, due to the harsh gastrointestinal environment, the viability and therapeutic efficacy of orally delivered bacteria are significantly...
The rational design of efficient and multifunctional electrocatalysts for energy conversion devices is one of the major challenges for clean and renewable energy transition. Herein, the local electronic structure of cobalt–platinum nanoclusters is regulated by adjacent platinum atomic site encapsulated in N‐doped hollow carbon nanotubes (PtSA–PtCo NCs/N–CNTs) by pyrolysis of melamine‐orientation‐induced...
Excessive accumulations of reactive oxygen species (ROS) and amyloid‐β (Aβ) protein are closely associated with the complex pathogenesis of Alzheimer's disease (AD). Therefore, approaches that synergistically exert elimination of ROS and dissociation of Aβ fibrils are effective therapeutic strategies for correcting the AD microenvironment. Herein, a novel near infrared (NIR) responsive Prussian blue‐based...
Heterogeneity and drug resistance of tumor cells are the leading causes of incurability and poor survival for patients with recurrent breast cancer. In order to accurately deliver the biological anticancer drugs to different subtypes of malignant tumor cells for omnidirectional targeted treatment of recurrent breast cancer, a distinct design is demonstrated by embedding liposome‐based nanocomplexes...
Electroreduction of CO2 to CO is a promising route for greenhouse gas resource utilization, but it still suffers from impractical current density and poor durability. Here, a nanosheet shell (NS) vertically standing on the Ag hollow fiber (NS@Ag HF) surface formed by electrochemical surface reconstruction is reported. As‐prepared NS@Ag HF as a gas penetration electrode exhibited a high CO faradaic...
The electrocatalytic CO2 reduction reaction (CO2RR) is an attractive technology for CO2 valorization and high‐density electrical energy storage. Achieving a high selectivity to C2+ products, especially ethylene, during CO2RR at high current densities (>500 mA cm−2) is a prized goal of current research, though remains technically very challenging. Herein, it is demonstrated that the surface and...
The high‐rate ethanol electrosynthesis from CO2 is challenging due to the low selectivity and poor activity, which requires the competition with other reduction products and H2. Here, the electrochemical reconstruction of Cs3Cu2Cl5 perovskite to form surface Cl‐bonded, low‐coordinated Cs modified Cu(200) nanocubes (CuClCs), is demonstrated. Density functional theory calculations reveal that the...
Ischemic stroke and systemic cancer are two of the leading causes of mortality. Hypoxia is a central pathophysiological component in ischemic stroke and cancer, representing a joint medical function. This function includes angiogenesis regulation. Vascular remodeling coupled with axonal outgrowth following cerebral ischemia is critical in improving poststroke neurological functional recovery. Antiangiogenic...
In heterogeneous catalysis, single‐atom catalysts are the frontier and important prototypes for many reactions, and revealing the intrinsic structure–activity relationship is presently a critical task, but remains challenging. In this work, water electrolysis and oxygen reduction performances of FeXYiN3‐i (X, Y = B, C, O, P and S; i = 0, 1) moiety in Fe–porphyrin are studied by the first‐principles...
Halide perovskites with various compositions are potential candidates in low‐dosage X‐ray detection due to their large sensitivity and tunable optoelectronic properties. Here, cations engineering induced dimensional evolution of halide perovskites between 0D, 2D, and 3D is reported. Centimeter‐sized 2D lead‐free perovskite single‐crystal of 4‐fluorophenethylammonium antimony iodide (FPEA3SbI6) is...
Polyphosphate (polyP) is one of the most compact inorganic polyanionic biopolymers that participates in various physiological processes. However, the development of polyP‐based nanomaterials is still in its infancy. Here, biocompatible polyphosphate‐manganese nanosheets are designed and synthesized by a hierarchical assembly strategy. The thickness and the lateral size of the resulting polyP‐Mn nanosheets...
Direct ammonia (NH3) synthesis from water and atmospheric nitrogen using sunlight provides an energy‐sustainable and carbon‐neutral alternative to the Haber–Bosch process. However, the development of such a route with high performance is impeded by the lack of effective charge transfer and abundant active sites to initiate the nitrogen reduction reaction (NRR). Here, the authors report efficient plasmon‐induced...
Anatase TiO2 is a promising anode material for lithium‐ion batteries (LIBs) and sodium‐ion batteries (SIBs) due to its high specific capacity, low cost, and excellent cycle stability. However, low electrical conductivity and poor Na+ ion transport in TiO2 limit its practical applications. Here, substantially boosted Na+ ion transport and charge transfer kinetics are demonstrated by constructing a...
The electrochemical CO2 reduction reaction (CO2RR) has great potential in realizing carbon recycling while storing sustainable electricity as hydrocarbon fuels. However, it is still a challenge to enhance the selectivity of the CO2RR to single multi‐carbon (C2+) product, such as C2H4. Here, an effective method is proposed to improve C2H4 selectivity by inhibiting the production of the other competitive...
Colloidal all‐inorganic perovskites nanocrystals (NCs) have emerged as a promising material for display and lighting due to their excellent optical properties. However, blue emissive NCs usually suffer from low photoluminescence quantum yields (PLQYs) and poor stability, rendering them the bottleneck for full‐color all‐perovskite optoelectronic applications. Herein, a facile approach is reported to...
Though significant advances are made in the arena of single‐cell electroanalysis, quantification of intracellular amino acids of human cells remains unsolved. Exemplified by l‐histidine (l‐His), this issue is addressed by a practical electrochemical nanotool synergizing the highly accessible nanopipette with commercially available synthetic DNAzyme. The fabricated nanotools are screened before operation...
To get carbon electrode with both excellent gravimetric and volumetric capacitances at high mass loadings is critical to supercapacitors. Herein, cracked defective graphene nanospheres (GNS) well meet above requirements. The morphology and structure of the GNS are controlled by polystyrene sphere template/glucose ratio, microwave heating time, and Fe content. The typical GNS with specific surface...
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