Search results for: Arthur A.M. Wilde

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article

Minimal defibrillation thresholds and the correlation with implant position in subcutaneous implantable‐defibrillator patients

Anne‐Floor B.E. Quast, Sarah W.E. Baalman, Willeke Van der Stuijt, Arthur A.M. Wilde, more

Journal of Cardiovascular Electrophysiology > 30 > 11 > 2441 - 2447

Background Since the introduction of the subcutaneous implantable‐defibrillator (S‐ICD) knowledge of factors elevating the defibrillation threshold (DFT), have increased. Optimal device positioning most likely results in a decrease in DFT. The PRAETORIAN score is a tool to systematically evaluate S‐ICD implant position and predict conversion success by estimating the DFT on a chest X‐ray. The objective...

article

SCN5A mutation type and topology are associated with the risk of ventricular arrhythmia by sodium channel blockers

Ahmad S. Amin, Yolan J. Reckman, Elena Arbelo, Anne M. Spanjaart, more

International Journal of Cardiology > 2018 > 266 > C > 128-132

Ventricular fibrillation in patients with Brugada syndrome (BrS) is often initiated by premature ventricular contractions (PVCs). Presence of SCN5A mutation increases the risk of PVCs upon exposure to sodium channel blockers (SCB) in patients with baseline type-1 ECG. In patients without baseline type-1 ECG, however, the effect of SCN5A mutation on the risk of SCB-induced arrhythmia is unknown. We...

article

Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome

Yoav Michowitz, Anat Milman, Georgia Sarquella-Brugada, Antoine Andorin, more

Heart Rhythm > 2018 > 15 > 9 > 1394-1401

The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series.The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS.The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted...

article

Clinical parameters to optimize patient selection for subcutaneous and transvenous implantable defibrillator therapy

Anne‐Floor B.E. Quast, Tom F. Brouwer, Fleur V.Y. Tjong, Arthur A.M. Wilde, more

Pacing and Clinical Electrophysiology > 41 > 8 > 990 - 995

Background The subcutaneous implantable cardioverter‐defibrillator (S‐ICD) lacks the antitachycardia pacing (ATP) capability of tranvenous ICDs (TV‐ICD). S‐ICD patient selection can be challenging as some patients may benefit from ATP. We aim to identify clinical predictors of ATP benefit, in order to improve patient selection for S‐ICD or TV‐ICD therapy. Methods De novo single‐ and dual‐chamber...

article

Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome

Arja Suzanne Vink, Sally-Ann B. Clur, Arthur A.M. Wilde, Nico A. Blom

Trends in Cardiovascular Medicine > 2018 > 28 > 1 > 64-75

Age- and gender-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of sex hormones on the QTc-interval are not known, testosterone appears to shorten the QTc-interval. In females, however, there is a more complex interaction between progesterone and estrogen. In patients with an impaired repolarization,...

article

Revisiting the sensitivity of sodium channel blocker testing in Brugada syndrome using obligate transmittance

Rafik Tadros, Arthur A.M. Wilde

International Journal of Cardiology > 2017 > 245 > C > 183-184

article

Penetrance of Hypertrophic Cardiomyopathy in Children Who Are Mutation Positive

Alexa M.C. Vermeer, Sally-Ann B. Clur, Nico A. Blom, Arthur A.M. Wilde, more

The Journal of Pediatrics > 2017 > 188 > C > 91-95

To investigate the presence of hypertrophic cardiomyopathy (HCM) at first cardiac evaluation and during follow-up and cardiac events in predictively tested children who are mutation positive.The study included 119 predictively tested children who were mutation positive, with a mean age of 12.1 years. A family history and clinical variables from all cardiac evaluations after predictive genetic testing...

article

In search of the holy grail in the channelopathy field: Proving pathogenicity of long QT syndrome–associated variants?

Arthur A.M. Wilde, Christopher Semsarian

Heart Rhythm > 2017 > 14 > 8 > 1180-1181

article

Channelopathies, genetic testing and risk stratification

Arthur A.M. Wilde, Ahmad Amin

International Journal of Cardiology > 2017 > 237 > C > 53-55

The cardiac channelopathies are a group of diseases with (disease-) specific electrocardiographic (ECG) characteristics and a disease-specific risk of sudden cardiac death (SCD). This group includes the Long QT Syndromes (LQTS), Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), Brugada Syndrome (BrS), Short QT Syndromes (SQTS), and Early Repolarization Syndrome (ERS). In the past 2 decades...

article

The future of sudden cardiac death research

Ahmad S. Amin, Arthur A.M. Wilde

Progress in Pediatric Cardiology > 2017 > 45 > C > 49-54

Sudden unexplained death (SUD) in the young is a rare but tragic event. As genetic cardiac causes underlie the majority of SUD cases, surviving family members with the same genetic substrate as their deceased relative may be at increased risk. Presently, the diagnostic strategy to young SUD victims and their families is yet not standardized, the underlying aetiology in an important fraction of cases...

article

Gain-of-function mutation in SCN5A causes ventricular arrhythmias and early onset atrial fibrillation

Krystien V. Lieve, Arie O. Verkerk, Svitlana Podliesna, Christian van der Werf, more

International Journal of Cardiology > 2017 > 236 > C > 187-193

Mutations in SCN5A, the gene encoding the α-subunit of the cardiac sodium channel (NaV1.5), are associated with a broad spectrum of inherited cardiac arrhythmia disorders. The purpose of this study was to identify the genetic and functional determinants underlying a Dutch family that presented with a combined phenotype of ventricular arrhythmias with a likely adrenergic component, either in isolation...

article

To Add or Not to Add Mitral Valve Surgery to Septal Myectomy in HOCM Patients

Jolanda Kluin, Arthur A.M. Wilde, Yigal Pinto, Lex A. van Herwerden

Journal of the American College of Cardiology > 2017 > 69 > 17 > 2250

article

Utility of Post-Mortem Genetic Testing in Cases of Sudden Arrhythmic Death Syndrome

Najim Lahrouchi, Hariharan Raju, Elisabeth M. Lodder, Efstathios Papatheodorou, more

Journal of the American College of Cardiology > 2017 > 69 > 17 > 2134-2145

Sudden arrhythmic death syndrome (SADS) describes a sudden death with negative autopsy and toxicological analysis. Cardiac genetic disease is a likely etiology.This study investigated the clinical utility and combined yield of post-mortem genetic testing (molecular autopsy) in cases of SADS and comprehensive clinical evaluation of surviving relatives.We evaluated 302 expertly validated SADS cases...

article

Truncating titin mutations are associated with a mild and treatable form of dilated cardiomyopathy

Joeri A. Jansweijer, Karin Nieuwhof, Francesco Russo, Edgar T. Hoorntje, more

European Journal of Heart Failure > 19 > 4 > 512 - 521

Aims Truncating titin mutations (tTTN) occur in 25% of dilated cardiomyopathy (DCM) cases, but the phenotype and severity of disease they cause have not yet been systematically studied. We studied whether tTTN variants are associated with a clinically distinguishable form of DCM. Methods and results We compared clinical data on DCM probands and relatives with a tTTN mutation (n = 45, n = 73), LMNA...

article

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

Charles Antzelevitch, Gan-Xin Yan, Michael J. Ackerman, Martin Borggrefe, more

Journal of Arrhythmia > 2016 > 32 > 5 > 315-339

article

Risk stratification in Brugada syndrome: Where is the finish line?

Pieter G. Postema, Arthur A.M. Wilde

Heart Rhythm > 2016 > 13 > 10 > 1955-1956

article

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

Charles Antzelevitch, Gan-Xin Yan, Michael J. Ackerman, Martin Borggrefe, more

Heart Rhythm > 2016 > 13 > 10 > e295-e324

article

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

Elisabeth M. Lodder, Pasquelena De Nittis, Charlotte D. Koopman, Wojciech Wiszniewski, more

The American Journal of Human Genetics > 2016 > 99 > 3 > 786

article

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

Elisabeth M. Lodder, Pasquelena De Nittis, Charlotte D. Koopman, Wojciech Wiszniewski, more

The American Journal of Human Genetics > 2016 > 99 > 3 > 704-710

GNB5 encodes the G protein β subunit 5 and is involved in inhibitory G protein signaling. Here, we report mutations in GNB5 that are associated with heart-rate disturbance, eye disease, intellectual disability, gastric problems, hypotonia, and seizures in nine individuals from six families. We observed an association between the nature of the variants and clinical severity; individuals with loss-of-function...

article

Brugada Syndrome and the Subcutaneous Implantable Cardioverter-Defibrillator

Louise R.A. Olde Nordkamp, Giulio Conte, Boudewijn R.A.M. Rosenmöller, Joppe L.F. Warnaars, more

Journal of the American College of Cardiology > 2016 > 68 > 6 > 665-666

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Search results for: Arthur A.M. Wilde

Minimal defibrillation thresholds and the correlation with implant position in subcutaneous implantable‐defibrillator patients

SCN5A mutation type and topology are associated with the risk of ventricular arrhythmia by sodium channel blockers

Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome

Clinical parameters to optimize patient selection for subcutaneous and transvenous implantable defibrillator therapy

Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome

Revisiting the sensitivity of sodium channel blocker testing in Brugada syndrome using obligate transmittance

Penetrance of Hypertrophic Cardiomyopathy in Children Who Are Mutation Positive

In search of the holy grail in the channelopathy field: Proving pathogenicity of long QT syndrome–associated variants?

Channelopathies, genetic testing and risk stratification

The future of sudden cardiac death research

Gain-of-function mutation in SCN5A causes ventricular arrhythmias and early onset atrial fibrillation

To Add or Not to Add Mitral Valve Surgery to Septal Myectomy in HOCM Patients

Utility of Post-Mortem Genetic Testing in Cases of Sudden Arrhythmic Death Syndrome

Truncating titin mutations are associated with a mild and treatable form of dilated cardiomyopathy

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

Risk stratification in Brugada syndrome: Where is the finish line?

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability

Brugada Syndrome and the Subcutaneous Implantable Cardioverter-Defibrillator

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