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Brain networks are unique in their capacity to modify synaptic structure while at the same time modulating neuronal firing properties. We investigated the interaction of these plastic network properties with overall network dynamics in large, biophysical neuronal network models. We modulated firing properties of individual neurons by simulating changing levels of acetylcholine (ACh), a key neurotransmitter...
The fine architecture of sleep-wake behavior shows a distinct dynamic structure with distributions of rat sleep and wake bout durations displaying qualitatively different profiles. Wake bout durations follow a power-law relation whereas sleep bout durations are exponentially distributed. We show that a physiologically-based sleep-wake regulatory network model with an underlying deterministic structure...
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