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We previously reported that stimulus properties of morphine can be assessed in a passive avoidance conditioning paradigm using a single dosing discrimination test. In this behavioral task, mice were trained to avoid electric footshock in a two-compartment shuttle-box by pairing morphine with shock in one compartment and saline with shock in the other compartment. In subsequent shock-free tests,...
The difficulty in assessing stimulus properties of drugs becomes apparent when the test drug, like morphine, carries both aversive and reinforcing effects at certain doses. Mice (ICR Crj strain) were trained in a passive avoidance conditioning using a two-compartment shuttle-box. On alternate days, morphine (3.0 mg/kg) was paired with shock in one compartment and saline with shock in the other compartment...
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