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Some herbal medicines, including Aconiti tuber (Aconitum carmichaeli Debeaux, Ranunculaceae), have been recognized as being effective for the treatment of a “peripheral uncomfortable feeling of cold (hie)”. We hypothesized that these compounds affect peripheral vascular function via the nitric oxide (NO) system, which leads to recovery from “hie”. To answer this question, we investigated Aconiti tuber-induced...
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