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We have demonstrated label-free and real-time detection of prostate specific antigen (PSA) in human serum using silicon nanowire field effect transistors (NW FETs) with Schottky contacts (Si-Ti). The NW FETs were fabricated from SOI material using high-resolution e-beam lithography, thin film vacuum deposition and reactive-ion etching processes eliminating complicated processes of doping and thermal...
We report about a label-free and fast assay based on nanowire field-effect transistor (NW FET) for determination of PSA in human serum. Functionalization of NWs was performed by a new method using 5 nm gold nanoparticles (GNPs), which provides oriented covalent attachment of antibody half-fragments via their thiol groups. We use the GNPs to increase the effective surface-to-volume ratio of the silicon...
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