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Small‐molecule stabilization of protein–protein interactions (PPIs) is a promising concept in drug discovery, however the question how to identify or design chemical starting points in a “bottom‐up” approach is largely unanswered. We report a novel concept for identifying initial chemical matter for PPI stabilization based on imine‐forming fragments. The imine bond offers a covalent anchor for site‐directed...
Am Computer lässt sich im chemischen Raum eine intuitive „Fitness“‐Landschaft erzeugen (siehe Bild; blau: mögliche Treffer, rot: nichtproduktive Treffer), an der sich die chemische Optimierung von Wirkstoffkandidaten orientieren kann. Dadurch können Irrwege vermieden und mehrere Eigenschaften auf einmal betrachtet werden, und Information aus sowohl aktiven als auch inaktiven Verbindungen wird optimal...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.