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The superoxide free radical (O 2•− ) has been viewed as a likely major contributor to aging. If this is correct, then superoxide dismutase (SOD), which removes O 2•− , should contribute to longevity assurance. In Caenorhabditis elegans, overexpression (OE) of the major cytosolic Cu/Zn-SOD, sod-1, increases life span. But is this increase caused by enhanced antioxidant defense?...
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