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Recent development of MeRIP-Seq enabled the global unbiased profiling of transcriptome-wide N6-Adenosine. With this technique, it is now possible to detect the RNA methylation sites under a specific condition or the differential methylation sites between two experimental conditions. However, as an affinity-based approach, MeRIP-Seq has yet provided base-pair resolution. A single methylation site reported...
Integrative clinical outcome prediction model called gene interaction regularized elastic net (GIREN) method is proposed in this paper. GIREN combines gene expression, methylation profiles, and gene interaction networks in order to reveal genomic and epigenomic features that bear important prognostic value. With GIREN, gene expression and DNA methylation profiles are first jointly analyzed in a linear...
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