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Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport...
Our understanding of ADAM10 function has undergone a striking evolution during the past 10 years. After its independent identification in the bovine brain (then termed MADM) and invertebrates (sup-17 in Caenorhabditiselegans and kuzbanian in Drosophila melanogaster) it was first characterized as a key player in the Notch pathway in both flies and nematodes and as a candidate Amyloid Precursor...
Resorption of bone depends on the combined action of osteoblast-like bone lining cells and osteoclasts. The bone lining cell plays an essential role in modulating the formation of the osteoclasts and in the mean time prepares the bone surface for these multinucleated bone resorbing cells to attach to. The osteoclast attaches to the bone and the resorption starts with lowering the pH at the resorption...
The lysosomal limiting membrane has multiple functions including acidification of the lysosomal matrix, sequestration of lysosomal enzymes, mediation of fusion events beween lysosomes and other organelles, and transport of degradation products to the cytoplasm. Lysosomal membrane proteins are usually highly glycosylated proteins decorating the luminal surface of lysosomal membranes. LAMP-1, LAMP-2...
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