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The effect of streptozotocin (STZ)-induced diabetes and a combination of chronic treatment with haloperidol (HPD) on dopamine (DA)D 2 , serotonin (5-HT) 5-HT 1A and 5-HT 2A receptors was investigated in rat brain. Rats were randomly assigned to one of four groups: vehicle-vehicle, STZ-vehicle, vehicle-HPD, and STZ-HPD groups. Four weeks after single administration...
The densities of dopamine-D 4 receptors were determined in postmortem samples of caudate nucleus from patients with schizophrenia (n = 9) and age-matched controls (n = 10). D 4 receptor binding was defined as the defined as the difference between binding sites labeled by [ 3 H]YM-09151-2 (D 2 + D 3 + D 4 receptors) and those by [ 3 H]raclopride,...
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