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In this paper, the effect of the α-scorpion toxin tityustoxin (TsTX) in the release of γ-[ 3 H]aminobutyric acid ([ 3 H]GABA) from rat brain cortical slices is described. The TsTX-stimulatory effect on the release of [ 3 H]GABA was dependent on incubation time and TsTX concentration, having an EC 50 of 0.33 μM. Tetrodotoxin (TTX) completely inhibited the TsTX action...
The venom of the Brazilian spider Phoneutria nigriventer possesses several neurotoxic polypeptidic fractions. Previous work has established that one of the toxic components, PhTx 3 , inhibited Ca 2+ -dependent glutamate release and the increase in cytosolic free Ca 2+ in response to membrane depolarization. In the present work, we investigated the effect of PhTx...
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