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Oligonucleotide duplexes in solution are captured between the tip of a scanning tunneling microscope and a gold substrate to measure the conductance of the molecule. On page 432, J. Hihath and co‐authors show that A:T rich RNA:DNA hybrids exhibit long‐range charge transport with a weak length‐dependence through the A:T pairs. Cover image by Yuanhui Li.
An extremely important biological component, RNA:DNA can also be used to design nanoscale structures such as molecular wires. The conductance of single adenine‐stacked RNA:DNA hybrids is rapidly and reproducibly measured using the break junction approach. The conductance decreases slightly over a large range of molecular lengths, suggesting that RNA:DNA can be used as an oligonucleotide wire.
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