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This article has been retracted at the request of the authors.Reason: There are problems with certain data produced by the lead author of the paper. Specifically, the perforin staining, and the preferential production of IFN-γ over lytic granule release by CD8+ T cells in response to neurons are not reproducible. Also, the magnitude of the difference in NKG2A expression by HSV-specific versus nonspecific...
This study challenges the concept that herpes simplex virus type 1 (HSV-1) latency represents a silent infection that is ignored by the host immune system, and suggests antigen-directed retention of memory CD8 + T cells. CD8 + T cells specific for the immunodominant gB 498-505 HSV-1 epitope are selectively retained in the ophthalmic branch of the...
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