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Innate immunity includes a cellular and a humoral arm. Long pentraxin 3 (PTX3) is a fluid phase pattern recognition molecule and a key component of the humoral arm of innate immunity. PTX3 is normally produced in response to microbial recognition or inflammatory signals by different immune or stromal cells. In the early phase of skin wound healing, Pentraxin 3 (PTX3)- deficiency was associated with...
The long pentraxin PTX3 is a soluble Pattern Recognition Molecule (sPRM) with non-redundant roles in resistance to selected pathogens, such as the opportunistic fungus Aspergillus fumigatus. PTX3 facilitates recognition and phagocytosis of fungal conidia mainly by polymorphonuclear neutrophils (PMNs) via Fcγ receptors (FcγRs) and alternative complement pathway (ACP) mechanisms. The human PTX3 protein...
The present study was designed to assess the effect ofN,N-dimethyl-3-[(1-benzyl-1H-indazol-3-yl)ossi]-1-propanamine (benzydamine) on in vivo and in vitro production of inflammatory cytokines. Benzydamine inhibited tumour necrosis factor-alpha (TNF-α) production in vitro by human lipopolysaccharide-stimulated monocytes with an ED 50 of 25 μM (12 donors). Under the same conditions, benzydamine...
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