Search results for: Tomoko Shima

Items from 1 to 20 out of 57 results

article

Immunological regulation and the role of autophagy in preeclampsia

Akitoshi Nakashima, Atsushi Furuta, Mihoko Yoshida‐Kawaguchi, Kiyotaka Yamada, more

American Journal of Reproductive Immunology > 91 > 3 > n/a - n/a

Autophagy is a bulk degradation system that maintains cellular homeostasis by producing energy and/or recycling excess proteins. During early placentation, extravillous trophoblasts invade the decidua and uterine myometrium, facing maternal immune cells, which participate in the immune suppression of paternal and fetal antigens. Regulatory T cells will likely increase in response to a specific antigen...

article

Efficacy and safety of fremanezumab for chronic migraine prevention: Multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group trial in Japanese and Korean patients

Fumihiko Sakai, Norihiro Suzuki, Byung‐Kun Kim, Hisaka Igarashi, more

Headache: The Journal of Head and Face Pain > 61 > 7 > 1092 - 1101

Objective To determine the efficacy and safety of fremanezumab administration in Japanese and Korean patients with chronic migraine (CM). Background Available preventive treatments for CM are limited by various efficacy and safety issues. Fremanezumab, a monoclonal antibody that targets the calcitonin gene‐related peptide pathway involved in migraine pathogenesis, has been shown to be effective...

article

Bone morphogenetic protein‐2 enhances gonadotropin‐independent follicular development via sphingosine kinase 1

Masami Ito, Osamu Yoshino, Yosuke Ono, Akemi Yamaki‐Ushijima, more

American Journal of Reproductive Immunology > 85 > 5 > n/a - n/a

Problem Pre‐ovulatory mature follicles are not readily induced from gonadotropin (Gn)‐independent early follicles in the poor ovarian response (POR) state, characterized by reduced number of retrieved oocytes. Bone morphogenetic protein (BMP), which is expressed in the ovary, contributes to early folliculogenesis, but its precise underlying mechanism remains unknown. The purpose of this study was...

article

Placental autophagy failure: A risk factor for preeclampsia

Akitoshi Nakashima, Tomoko Shima, Aiko Aoki, Mihoko Kawaguchi, more

Journal of Obstetrics and Gynaecology Research > 46 > 12 > 2497 - 2504

Hypertensive disorders of pregnancy, including preeclampsia, directly affect maternal and perinatal morbidity and mortality. As the pathophysiology of preeclampsia is multi‐factorial and has been studied using different approaches, we have demonstrated that impaired autophagy is an intertwined risk factor for preeclampsia. This concept has been verified in both in vitro and in vivo experiments. Autophagy...

article

Decreased effector regulatory T cells and increased activated CD4⁺ T cells in premature ovarian insufficiency

Mutsumi Kobayashi, Akitoshi Nakashima, Osamu Yoshino, Masanori Yoshie, more

American Journal of Reproductive Immunology > 81 > 6 > n/a - n/a

Problem Premature ovarian insufficiency (POI) is a clinical syndrome defined by the loss of ovarian activity before 40 years old. An autoimmune mechanism is suggested to be involved in the development of POI. Therefore, we examined the relationship between peripheral blood regulatory T (Treg) cells and autoantibodies in POI. Method of study Thirty POI patients and 23 control women were enrolled...

article

Repeated hyperhidrosis and chilblain‐like swelling with ulceration of the fingers and toes in hereditary sensory and autonomic neuropathy type II

Tomoko Shima, Yuki Yamamoto, Nobuo Kanazawa, Ken‐ya Murata, more

The Journal of Dermatology > 45 > 11 > e308 - e309

article

Three cases of clear‐cell adenocarcinoma arising from endometrioma during hormonal treatments

Osamu Yoshino, Takashi Minamisaka, Yosuke Ono, Sayaka Tsuda, more

Journal of Obstetrics and Gynaecology Research > 44 > 9 > 1850 - 1858

Endometrioma is known to be an occurrence site of ovarian cancer, but there is no evidence on how to reduce the risk of canceration. Here, we report three cases of ovarian cancer arising from endometrioma during hormone therapies of GnRH analogue and tamoxifen, low‐dose estrogen‐progestin (LEP) and dienogest. In all cases, each hormonal treatment was effective in shrinking the size of the endometrioma...

article

In which preterm labor‐patients is intravenous maintenance tocolysis effective?

Satoshi Yoneda, Noriko Yoneda, Kaori Fukuta, Tomoko Shima, more

Journal of Obstetrics and Gynaecology Research > 44 > 3 > 397 - 407

Aim We evaluated whether maintenance tocolysis (intravenous ritodrine hydrochloride and/or magnesium sulfate) was effective in cases of spontaneous preterm labor with intact membranes. Methods One hundred and thirty preterm labor patients who reached 36 weeks of gestation by maintenance tocolysis were selected. Immediate delivery (ID) after ceasing maintenance tocolysis was defined as an ‘effective...

article

MicroRNA expression analysis of peripheral and decidual natural killer cells in early miscarriage

Manabu Ogoyama, Akihide Ohkuchi, Tomoko Shima, Shigeru Saito, more

Journal of Reproductive Immunology > 2017 > 124 > C > 83

article

Impaired autophagy and transthyretin protein aggregation in early onset preeclampsia

Akitoshi Nakashima, Tae Kusabiraki, Aiko Aoki, Akemi Ushijima, more

Journal of Reproductive Immunology > 2017 > 124 > C > 71-72

article

Placental-specific microRNAs were transferred into decidual natural killer cells in the first trimester of pregnancy

Manabu Ogoyama, Akihide Ohkuchi, Tomoko Shima, Shigeru Saito, more

Placenta > 2017 > 59 > C > 174

article

M1 macrophages are involved in folliculogenesis and M2 macrophages play an essential role for successful implantation

Yosuke Ono, Miwako Nagai, Osamu Yoshino, Kaori Koga, more

Journal of Reproductive Immunology > 2017 > 124 > C > 72

article

Clonal populations of effector regulatory T cell increase in human decidua of late pregnancy

Sayaka Tsuda, Hiroyuki Kishi, Tomoko Shima, Hiroshi Hamana, more

Journal of Reproductive Immunology > 2017 > 124 > C > 82

article

PAI‐1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF‐β and TNF‐α in mononuclear cells by insulin‐sensitizing drugs

Kaori Yamada‐Nomoto, Osamu Yoshino, Ikumi Akiyama, Akira Iwase, more

American Journal of Reproductive Immunology > 78 > 1 > n/a - n/a

Problem Plasminogen activator inhibitor‐1 (PAI‐1) is elevated in women with polycystic ovary syndrome (PCOS), but the regulation in granulosa cells (GCs) is unclear. Method of study PAI‐1 expression in PCOS ovaries was investigated immunohistologically. PAI‐1 expressions in HGrC1, a human GC cell line, were investigated at mRNA and activity levels. The expressions of TGF‐β and TNF‐α in peritoneal...

article

Role of autophagy in oocytogenesis, embryogenesis, implantation, and pathophysiology of pre‐eclampsia

Akitoshi Nakashima, Aiko Aoki, Tae Kusabiraki, Tomoko Shima, more

Journal of Obstetrics and Gynaecology Research > 43 > 4 > 633 - 643

Autophagy is a well‐conserved mechanism in cells from yeast to mammals, and autophagy maintains homeostasis against stress. The role of autophagy was originally shown to be a mechanism of energy production under starvation. In fact, multiple lines of evidence reveal that autophagy has numerous functions, such as protection from stress, energy regulation, immune regulation, differentiation, proliferation,...

article

Alpha‐7 nicotinic acetylcholine receptor (nAChR) agonist inhibits the development of endometriosis by regulating inflammation

Kaori Yamada‐Nomoto, Osamu Yoshino, Ikumi Akiyama, Akemi Ushijima, more

American Journal of Reproductive Immunology > 76 > 6 > 491 - 498

Objective We investigated α‐7 nAchR expression in human peritoneal macrophages and examined whether activation of nAchR might be a new therapy for endometriosis. Materials and methods Human peritoneal fluid mononuclear cells (PFMC) were stimulated with lipopolysaccharide (LPS) in the presence of α‐7 nAChR agonists. In a murine endometriosis model, α‐7 nAChR modulators were administered. Results...

article

The presence and the role of S1P system in endometriosis

Osamu Yoshino, Kaori Yamada-Nomoto, Yosuke Ono, Akitoshi Nakashima, more

Journal of Reproductive Immunology > 2016 > 118 > C > 127

article

Paternal antigen specific immune-tolerance for implantation and maintenance of pregnancy

Tomoko Shima, Akemi Ushijima, Sayaka Tsuda, Kumiko Inada, more

Journal of Reproductive Immunology > 2016 > 118 > C > 147

article

The priming of seminal fluid induces tolerogenic dendritic cells in allogeneic mating mice resulting in increase of paternal antigen-specific Treg cells

Akemi Ushijima, Tomoko Shima, Kumiko Inada, Akitoshi Nakashima, more

Journal of Reproductive Immunology > 2016 > 118 > C > 110

article

Preeclampsia (PE) serum disrupts the autophagy/lysosome pathway cooperated with endoplasmic reticulum (ER) stress

Akitoshi Nakashima, Tomoko Shima, Aiko Aoki, Kumiko Inada, more

Placenta > 2016 > 46 > C > 118

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Keywords

PREECLAMPSIA (7)
PREGNANCY (6)
MISCARRIAGE (5)
AUTOPHAGY (4)
INFLAMMATION (4)
EFFECTOR TREG (3)
PRETERM LABOR (3)
REGULATORY T CELLS (3)
TOLERANCE (3)
ABORTION (2)
AMNIOTIC FLUID (2)
DECIDUA (2)
FOXP3 (2)
HELIOS (2)
HUMAN PREGNANCY (2)
HYPOXIA (2)
IMPLANTATION (2)
LYMPHOCYTE (2)
MOLECULAR EPIDEMIOLOGY (2)
MOLECULAR TYPING (2)
OVARIAN CANCER (2)
PRE‐ECLAMPSIA (2)
REGULATORY T CELL (2)
TREG (2)
LEGIONELLA PNEUMOPHILA (1)
4NQO (1)
ADENOCARCINOMA (1)
ALLODYNIA (1)
ALLOGRAFT REJECTION (1)
AMNIOTIC FLUID INTERLEUKIN‐8 (1)
ANGIOGENIC FACTOR (1)
ANGIOTENSIN RECEPTOR BLOCKERS (1)
ANTIBIOTIC THERAPY (1)
ANTI‐THYROGLOBULIN ANTIBODY (1)
AUTOANTIBODY (1)
AUTOIMMUNE DISEASE (1)
AUTOIMMUNE OOPHORITIS (1)
BLOOD PRESSURE (1)
BODY MASS INDEX (1)
BONE MORPHOGENETIC PROTEIN (BMP) (1)
CALCITONIN GENE‐RELATED PEPTIDE (1)
CALCIUM CHANNEL BLOCKERS (1)
CD25 (1)
CD279 (1)
CD4+CD25+ REGULATORY T CELL (1)
CD4+CD25+ REGULATORY T CELLS (1)
CELLIMMUNO (1)
CENTRAL NERVOUS SYSTEM (1)
CERCLAGE (1)
CEREBRAL METASTASIS (1)
CHEMOKINE RECEPTOR (1)
CHEMOTHERAPY (1)
CHRONIC MIGRAINE (1)
CLINICAL STAGE (1)
COMBINATION ANTIHYPERTENSIVE DRUGS (1)
CONSERVATIVE SURGERY (1)
CTLA-4 (1)
CYTOKINE NETWORK (1)
DECIDUA BASALIS (1)
DECIDUAL NK CELL (1)
ENCEPHALITIS (1)
ENDOMETRIOMA (1)
ENDOMETRIOSIS (1)
ER STRESS (1)
EXHAUSTED TREG (1)
EXTRATHYMIC TREG (1)
EXTRAVILLOUS TROPHOBLAST (1)
FALLOPIAN TUBE CARCINOMA (1)
FETAL CHROMOSOME (1)
FETAL FIBRONECTIN (1)
FETO-MATERNAL TOLERANCE (1)
FREMANEZUMAB (1)
GALECTIN-1 (1)
GONADOTROPIN‐INDEPENDENT EARLY FOLLICULAR DEVELOPMENT (1)
GRANULOSA CELL (1)
GRANULYSIN (1)
HASHIMOTO THYROIDITIS (1)
HERBAL MEDICINE (1)
HER‐2 (1)
HETEROGENEITY OF TREG (1)
HIPPO PATHWAY (1)
HORMONAL THERAPY (1)
HUMAN CELLS (1)
HYDROXYCHLOROQUINE (1)
HYPERALGESIA (1)
HYPERTENSION (1)
IDO (1)
IMMORTALIZATION (1)
IMMUNE ETIOLOGY (1)
IMMUNE MODULATION (1)
IMMUNE TOLERANCE (1)
IMMUNOACTIVATION (1)
IMMUNOMALADAPTATION (1)
IMMUNOSUPPRESSION (1)
INFERTILITY (1)
INTERLEUKIN‐8 (1)
INVASION (1)
JAPANESE (1)
KOREAN (1)
LEGIONELLA PNEUMOPHILA (1)
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Elsevier (29)
Wiley (22)
Springer (6)

INFONA - science communication portal

Search results for: Tomoko Shima

Immunological regulation and the role of autophagy in preeclampsia

Efficacy and safety of fremanezumab for chronic migraine prevention: Multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group trial in Japanese and Korean patients

Bone morphogenetic protein‐2 enhances gonadotropin‐independent follicular development via sphingosine kinase 1

Placental autophagy failure: A risk factor for preeclampsia

Decreased effector regulatory T cells and increased activated CD4⁺ T cells in premature ovarian insufficiency

Repeated hyperhidrosis and chilblain‐like swelling with ulceration of the fingers and toes in hereditary sensory and autonomic neuropathy type II

Three cases of clear‐cell adenocarcinoma arising from endometrioma during hormonal treatments

In which preterm labor‐patients is intravenous maintenance tocolysis effective?

MicroRNA expression analysis of peripheral and decidual natural killer cells in early miscarriage

Impaired autophagy and transthyretin protein aggregation in early onset preeclampsia

Placental-specific microRNAs were transferred into decidual natural killer cells in the first trimester of pregnancy

M1 macrophages are involved in folliculogenesis and M2 macrophages play an essential role for successful implantation

Clonal populations of effector regulatory T cell increase in human decidua of late pregnancy

PAI‐1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF‐β and TNF‐α in mononuclear cells by insulin‐sensitizing drugs

Role of autophagy in oocytogenesis, embryogenesis, implantation, and pathophysiology of pre‐eclampsia

Alpha‐7 nicotinic acetylcholine receptor (nAChR) agonist inhibits the development of endometriosis by regulating inflammation

The presence and the role of S1P system in endometriosis

Paternal antigen specific immune-tolerance for implantation and maintenance of pregnancy

The priming of seminal fluid induces tolerogenic dendritic cells in allogeneic mating mice resulting in increase of paternal antigen-specific Treg cells

Preeclampsia (PE) serum disrupts the autophagy/lysosome pathway cooperated with endoplasmic reticulum (ER) stress

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