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The tissue-specific toxicity of the herbicide, dichlobenil (2,6-dichlorobenzonitrile), in the olfactory mucosa is related to a cytochrome P450 (P450)-dependent metabolism, depletion of glutathione and covalent binding of metabolites. Pretreatment of mice with diethyldithiocarbamate (DEDTC) protected against the dichlobenil-induced necrosis. Addition of DEDTC abolished the covalent binding of [ ...
The irreversible binding and toxicity of the olfactory toxicant dichlobenil in the mouse perinatal olfactory mucosa were examined by autoradiography and histopathology. In the olfactory mucosa of adult mice the irreversible binding of [ 14 C]dichlobenil-derived radioactivity is confined to the Bowman's glands. The results in this study showed a low irreversible binding of [ 1 ...
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