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The fibrinolytic system has been related to the etiopathogenesis of arteriosclerosis. The generation of plasmin in the arterial wall could activate MMPs.Purposes: To determine any functional differences of the fibrinolytic system between atheromas found in the carotid artery, aorta and femoral artery and their relationship to plasma levels of PAI and DD.Material and Methods: Samples of plasma and...
Diverse reports have evidenced the presence of message (mRNA) and protein for t-PA, u-PA and PA1-1 in human artery segments, however, neither production kinetics nor actual plasmin-generating activity have been described. Functional plasmin is important not only as fibrinolytic agent but also as activator of metalloproteinases.Objective: To study the regulation of fibrinolytic (plasmin-generating)...
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