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In various gastrointestinal smooth muscles, two different muscarinic receptor subtypes, M2 and M3, are expressed; these receptors are the target for the parasympathetic neurotransmitter acetylcholine. Although the number of M2 receptors is much greater than that of M3 receptors, the functional role of the former receptor subtype has yet to be fully defined, since pharmacological analyses of the contractile...
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