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RNA interference targeting RelB can significantly attenuate ischemia/reperfusion (I/R)-induced renal dysfunction, but its roles in liver I/R injury remain to be defined. We have investigated whether siRNA targeting of RelB in liver could also elicit protection against I/R injury.A RelB miRNA RNAi expression plasmid, a scrambled plasmid, or phosphate-buffered saline (50 μg of the plasmid diluted in...
To investigate whether hypoxia-inducible factor (HIF) 1α and cyclosporin A (CsA) can regulate MICA/B expression and affect NK cytotoxicity during ischemia/reperfusion (I/R) injury.We generated an HIF-1αΔODD-expressing adenovirus which can functionally and steadily express HIF-1α during normoxia and transfected human cardiomyocytes (HCMs) to investigate whether HIF-1α, as a single factor, can upregulate...
The expression of hypoxia-inducible factor-1α (HIF-1α) in heart allografts is an important mechanism in response to ischemia/reperfusion (I/R) injury which represents the single major non-immunologic factor implicated in pathogenesis of chronic graft dysfunction (CGD). Adenoviral mediated overexpression of HIF-1α is a useful way to investigate the molecular mechanisms of I/R injury and the cardiac...
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