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Malignant brain tumors are known to utilize acetate as an alternate carbon source in the citric acid cycle for their bioenergetics. 13C NMR‐based isotopomer analysis has been used to measure turnover of 13C‐acetate carbons into glutamate and glutamine pools in tumors. Plasma from the patients infused with [1,2‐13C]acetate further revealed the presence of 13C isotopomers of glutamine, glucose, and...
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