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Purpose
To generate a preclinical model of isocitrate dehydrogenase (IDH) mutant gliomas from glioma patients and design a MRS method to test the compatibility of 2‐hydroxyglutarate (2HG) production between the preclinical model and patients.
Methods
Five patient‐derived xenograft (PDX) mice were generated from two glioma patients with IDH1 R132H mutation. A PRESS sequence was tailored at 9.4 T,...
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