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Although T cells are able to recognize a wide variety of target peptides, they are often strongly focused on a few of the peptides and leave the rest of them unattended. This phenomenon of strongly biased immune response is known as immunodominance. Mathematically, an immunodominance problem can be formulated using optimal control principles as a two-point boundary-value problem. The solution of this...
This paper describes a dynamics modeling and control strategy of a chemo-electro-mechanical process for electroporation-mediated gene delivery. By extending the results in the open literature, a control-enabled dynamics model of the gene-delivery process is proposed. Based on the dynamics model, a model-based state feedback control strategy is proposed. Simulation results are provided to demonstrate...
This paper presents an automated DNA and protein microarray fabrication system using inkjet technology. The hardware of the system consists of a high-precision motion system, a robotic material handling system, computer control systems, and extensive vision systems. The software of the system includes sophisticated algorithms to handle control, communication, and manufacturing process information...
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