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Orexin‐A (hypocretin‐1) and orexin‐B (hypocretin‐2) are hypothalamic neuropeptides that play key roles in the regulation of wakefulness, feeding, reward, autonomic functions and energy homeostasis. To control these functions indispensable for survival, orexin‐expressing neurones integrate peripheral metabolic signals, interact with many types of neurones in the brain and modulate their activities...
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