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Programmed ribosomal bypassing occurs in decoding phage T4 gene 60 mRNA. Half the ribosomes bypass a 50 nucleotide gap between codons 46 and 47. Peptidyl-tRNA dissociates from the “take-off” GGA, codon 46, and re-pairs to mRNA at a matched GGA “landing site” codon directly 5′ of codon 47 where translation resumes. The system described here allows the contribution of peptidyl-tRNA re-pairing to be...
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